The Central Bank faced multiple challenges in 2021, especially due to the consequences of the worst period of the pandemic, which continued to affect the normal functioning of the economy. The persistence of the health crisis substantially changed the ways in which people, institutions, and the financial word interact, raising a huge digitization challenge. In addition to adopting the necessary measures to continue fulfilling the mandate established in the Bank’s Basic Constitutional Act, we faced new scenarios that require strengthening innovation and the search for better ways to contribute to sustainable development.